The programmed death (PD)-1/PD-ligand 1 pathway regulates graft-versus-host-reactive CD8 T cells after liver transplantation.

@article{Schuchmann2008ThePD,
  title={The programmed death (PD)-1/PD-ligand 1 pathway regulates graft-versus-host-reactive CD8 T cells after liver transplantation.},
  author={Marcus Schuchmann and Ralph G. Meyer and Eva Distler and Esther von Stebut and J{\"u}rgen H E Kuball and Elke Schn{\"u}rer and Thomas Woelfel and Matthias Theobald and Abdo Konur and Sebastian Paul Gregor and O. Schreiner and Christian Huber and Peter Robert Galle and Georg Otto and Wolfgang Herr},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2008},
  volume={8 11},
  pages={2434-44}
}
Acute graft-versus-host disease (aGVHD) is a life-threatening complication after solid-organ transplantation, which is mediated by host-reactive donor T cells emigrating from the allograft. We report on two liver transplant recipients who developed an almost complete donor chimerism in peripheral blood and bone marrow-infiltrating T cells during aGVHD. By analyzing these T cells directly ex vivo, we found that they died by apoptosis over time without evidence of rejection by host T cells. The… CONTINUE READING