The prognostic value of phosphatase and tensin homolog negativity in breast cancer: A systematic review and meta-analysis of 32 studies with 4393 patients.

@article{Yang2016ThePV,
  title={The prognostic value of phosphatase and tensin homolog negativity in breast cancer: A systematic review and meta-analysis of 32 studies with 4393 patients.},
  author={Zuyao Yang and Yuan-Yuan Yu and J Yuan and Wei-xi Shen and Da-yong Zheng and Jin-zhang Chen and Chen Mao and Jin-Ling Tang},
  journal={Critical reviews in oncology/hematology},
  year={2016},
  volume={101},
  pages={40-9}
}
The prognostic value of phosphatase and tensin homolog (PTEN) negativity in breast cancer has been evaluated by many studies but remains controversial. We conducted a meta-analysis to assess the association of PTEN negativity with overall survival and disease-free survival. Thirty-two studies with 4393 patients were identified. PTEN negativity was significantly associated with unfavorable overall survival in breast cancer (hazard ratio=1.89, 95% confidence interval 1.58-2.26), with low… CONTINUE READING