The prognostic value of c-erbB2 in primary breast carcinomas: A study on 942 cases

@article{Qunel1995ThePV,
  title={The prognostic value of c-erbB2 in primary breast carcinomas: A study on 942 cases},
  author={Nathalie Qu{\'e}nel and Jean Wafflart and Françoise Bonichon and Isabelle de Mascarel and Monique Trojani and Michel Durand and Antoine Avril and J. M. Coindre},
  journal={Breast Cancer Research and Treatment},
  year={1995},
  volume={35},
  pages={283-291}
}
To assess the practical prognostic value of c-erbB2, we performed a study on 942 invasive ductal carcinomas treated with primary surgery between 1980 and 1986 in our center. We evaluated its expression by immunohistochemistry in paraffin-embedded tissue using a polyclonal antipeptide antibody. Of 942 tumors, 229 (24%) showed a positive membrane staining. We observed a significant association between c-erbB2 and Scarff-Bloom-Richardson grading (p < 0.0001) and a negative correlation between c… CONTINUE READING

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