The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness.

@article{Rossi2009ThePV,
  title={The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness.},
  author={Davide Rossi and Michaela Cerri and Clara Deambrogi and Elisa Sozzi and Stefania Cresta and Silvia Rasi and Lorenzo De Paoli and Valeria Spina and Valter Gattei and Daniela Capello and Francesco Forconi and Francesco Nicola Lauria and Gianluca Gaidano},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 3},
  pages={995-1004}
}
PURPOSE Del17p13 predicts poor outcome and chemorefractoriness in chronic lymphocytic leukemia (CLL). Conversely, it is unknown whether TP53 mutations carry any prognostic value independent of del17p13. We tested the independent prognostic value of TP53 mutations in CLL. EXPERIMENTAL DESIGN The study was based on a consecutive series of 308 CLL. DNA sequencing of TP53 exons 2 to 10 and del17p13 interphase fluorescence in situ hybridization were done at CLL diagnosis. Study end points were… CONTINUE READING
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