The prognostic value of BRCA1 promoter methylation in early stage triple negative breast cancer

Abstract

INTRODUCTION Methylation of the BRCA1 promoter is frequent in triple negative breast cancers (TNBC) and results in a tumor phenotype similar to BRCA1-mutated tumors. BRCA1 mutation-associated cancers are more sensitive to DNA damaging agents as compared to conventional chemotherapy agents. It is not known if there is an interaction between the presence of… (More)
DOI: 10.7243/2049-7962-3-2

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