The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer.

  title={The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer.},
  author={Arezo Ghanipour and Karin Jirstr{\"o}m and Fredrik Ponten and Bengt Glimelius and Lars A P{\aa}hlman and Helgi Birgisson},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={18 11},
BACKGROUND Tryptophanyl-tRNA synthetase (TrpRS) is an aminoacyl-tRNA synthetase involved in protein synthesis and regulation of RNA transcription and translation and is an inhibitor of angiogenesis. TrpRS has been shown to be differentially expressed in colorectal cancer (CRC) and has thus been identified as a potential prognostic marker. The aim of this study was to analyze the correlation of TrpRS to the prognosis of patients diagnosed and treated for CRC within a defined population… CONTINUE READING


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