The prognostic significance of proliferating cell nuclear antigen in clinical gastric cancer.

@article{Mori1993ThePS,
  title={The prognostic significance of proliferating cell nuclear antigen in clinical gastric cancer.},
  author={Masaki Mori and Yoshihiro Kakeji and Yosuke Adachi and Sunao Moriguchi and Yoshihiko Maehara and Keishi Sugimachi and John Milburn Jessup and Lan Bo Chen and Glenn D. Steele},
  journal={Surgery},
  year={1993},
  volume={113 6},
  pages={683-90}
}
BACKGROUND Proliferating cell nuclear antigen (PCNA) is an intranuclear protein that is closely linked to the cell cycle. This antigen can be detected in formalin-fixed specimens. We studied the expression of PCNA in primary gastric cancer to identify its significance as a prognostic factor. METHODS The avidin-biotin-peroxidase complex method was used for PCNA staining in sections from 138 patients with primary gastric cancer. All sections were formalin fixed and paraffin embedded. Two… CONTINUE READING