The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas.

@article{Chakravarti2004ThePS,
  title={The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas.},
  author={Arnab Chakravarti and Gary Guotang Zhai and Yoshiyuki Suzuki and Sormeh Sarkesh and Peter M. Black and Alona Muzikansky and Jay Steven Loeffler},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2004},
  volume={22 10},
  pages={1926-33}
}
PURPOSE The objectives of this study were to examine activation patterns of the phosphatidylinositol 3-kinase (PI3K) pathway in gliomas and to examine the prognostic significance of PI3K pathway activation using snap-frozen clinical specimens. MATERIALS AND METHODS Levels of expression of PI3K pathway members were assessed in 92 prospectively collected gliomas through quantitative Western analysis using total and phospho-specific antibodies for PI3K, Akt, and p70(s6k). Both expression and… CONTINUE READING
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