The prognostic significance of patient-reported outcomes in cancer clinical trials.

  title={The prognostic significance of patient-reported outcomes in cancer clinical trials.},
  author={Carolyn Gotay and Crissy Terawaki Kawamoto and Andrew Bottomley and Fabio Efficace},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={26 8},
PURPOSE Patient-reported outcomes (PROs), routinely collected as a part of cancer clinical trials, have been linked with survival in numerous clinical studies, but a comprehensive critical review has not been reported. This study systematically assessed the impact of PROs on patient survival after a cancer diagnosis within the context of clinical trials. DESIGN Cancer clinical trials that assessed baseline PROs and mortality were identified through MEDLINE (through December 2006) supplemented… CONTINUE READING
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