The prognostic significance of nuclear DNA content in malignant epithelial tumors of the ovary.

@article{Brescia1990ThePS,
  title={The prognostic significance of nuclear DNA content in malignant epithelial tumors of the ovary.},
  author={R J Brescia and Richard Barakat and Uzi Beller and Greg N. Frederickson and Mark J Suhrland and Neil Dubin and Rita I. Demopoulos},
  journal={Cancer},
  year={1990},
  volume={65 1},
  pages={141-7}
}
Recent studies have indicated that the nuclear DNA content of certain malignant neoplasms can be used as an adjunct in predicting their biologic behavior. The DNA content of 99 ovarian carcinomas was determined by flow cytometric analysis of nuclei obtained from paraffin-embedded tissue. Of the 99 tumors, 51 were diploid and 48 showed one or more aneuploid peaks. The 5-year survival for patients with diploid tumors (50%) was significantly higher than for patients with aneuploid tumors (22%) (P… CONTINUE READING

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