The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer

Abstract

BackgroundMutations in KRAS, BRAF, PIK3CA and PTEN expression have been in focus to predict the effect of epidermal growth factor receptor-blocking therapy in colorectal cancer (CRC). Here, information on these four aberrations was collected and combined to a Quadruple index and used to evaluate the prognostic role of these factors in CRC.PatientsWe… (More)
DOI: 10.1038/bjc.2013.212

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