The prognostic relevance of flt3 and npm1 mutations on older patients treated intensively or non-intensively: a study of 1312 patients in the UK NCRI AML16 trial

@article{Lazenby2014ThePR,
  title={The prognostic relevance of flt3 and npm1 mutations on older patients treated intensively or non-intensively: a study of 1312 patients in the UK NCRI AML16 trial},
  author={Michelle Lazenby and Amanda F. Gilkes and Ceri Marrin and Anna C Evans and Robert K. Hills and Alan K. Burnett},
  journal={Leukemia},
  year={2014},
  volume={28},
  pages={1953-1959}
}
Although the prognostic impact of mutations of FLT3 and NPM1 have been extensively studied in younger patients with acute myeloid leukaemia, less is known in older patients whether treated intensively or non-intensively, or in the context of existing prognostic scores. In 1312 patients 16 and 21%, respectively had an FLT3 and NPM1 mutation. An FLT3 mutation did not affect remission rate in intensively or non-intensively treated patients but was associated with an inferior survival. All patients… CONTINUE READING
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