The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism.

@article{Batista2016ThePI,
  title={The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism.},
  author={Rui F. Batista and Adriana Cruvinel-Carloni and Jo{\~a}o Vinagre and Joana Peixoto and Telmo A. Catarino and Nath{\'a}lia Cristina Campanella and Weder P Menezes and Aline Nazareth Paix{\~a}o Becker and Gisele Caravina de Almeida and Marcus de Medeiros Matsushita and Carlos Afonso Clara and Luciano Serafin Neder and Marta Viana-Pereira and Mrinalini Honavar and L{\'i}gia Prado e Castro and Jos{\'e} Manuel Lopes and Bruno F. Carvalho and Rui Vaz and Valdemar M{\'a}ximo and Paula Soares and Manuel Sobrinho-Sim{\~o}es and Rui Manuel Reis and Jorge Lima},
  journal={International journal of cancer},
  year={2016},
  volume={139 2},
  pages={414-23}
}
Human hotspot TERT promoter (TERTp) mutations have been reported in a wide range of tumours. Several studies have shown that TERTp mutations are associated with clinicopathological features; in some instances, TERTp mutations were considered as biomarkers of poor prognosis. The rs2853669 SNP, located in the TERT promoter region, was reported to modulate the increased TERT expression levels induced by the recurrent somatic mutations. In this study we aimed to determine the frequency and… CONTINUE READING