The prognostic and functional role of microRNAs in acute myeloid leukemia.

@article{Marcucci2011ThePA,
  title={The prognostic and functional role of microRNAs in acute myeloid leukemia.},
  author={Guido Marcucci and Krzysztof Mr{\'o}zek and Michael D. Radmacher and Ramiro Garzon and Clara D. Bloomfield},
  journal={Blood},
  year={2011},
  volume={117 4},
  pages={1121-9}
}
Expression of microRNAs, a new class of noncoding RNAs that hybridize to target messenger RNA and regulate their translation into proteins, has been recently demonstrated to be altered in acute myeloid leukemia (AML). Distinctive patterns of increased expression and/or silencing of multiple microRNAs (microRNA signatures) have been associated with specific cytogenetic and molecular subsets of AML. Changes in the expression of several microRNAs altered in AML have been shown to have functional… CONTINUE READING

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