The progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of breast cancer in Australian women.

@article{Spurdle2002ThePR,
  title={The progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of breast cancer in Australian women.},
  author={Amanda B. Spurdle and John L Hopper and Xiaoqing Chen and Margaret R. E. McCredie and Graham G. Giles and Deon J. Venter and Melissa C. Southey and Georgia Chenevix-Trench},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2002},
  volume={11 5},
  pages={
          439-43
        }
}
An Alu insertion polymorphism of the progesterone receptor (PR) wasreported recently to be associated with a reduced risk of breast cancer, with risks of 0.8- and 0.3-fold associated with the heterozygote and homozygote genotypes, respectively. This intronic variant is considered to be in linkage disequilibrium with an exon 4 hinge region G to T Val660Leu polymorphism. We investigated whether the exon 4 PR polymorphism was associated with breast cancer in Australian women, using a population… CONTINUE READING

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