Corpus ID: 39692076

The progesterone receptor antagonist mifepristone does not lower serum progesterone induced blocking factor (PIBF) in the presence of progesterone.

@article{Check2016ThePR,
  title={The progesterone receptor antagonist mifepristone does not lower serum progesterone induced blocking factor (PIBF) in the presence of progesterone.},
  author={J. Check and G. DiAntonio and A. Diantonio and M. Duroseau},
  journal={Clinical and experimental obstetrics \& gynecology},
  year={2016},
  volume={43 2},
  pages={
          189-91
        }
}
PURPOSE To determine if mifepristone can lower serum levels of a progesterone (P) induced immunomodulatory protein believed to be needed for the fetus to escape immune surveillance. MATERIALS AND METHODS A female volunteer had her serum P induced blocking factor (PIBF) increased by ingestion of oral micronized P. While remaining on P mifepristone, 200 mg/day was given for six days when another serum PIBF level was obtained. RESULTS The serum PIBF was 273 ng/ml after five days of oral… Expand
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