The progesterone-induced blocking factor modulates the balance of PKC and intracellular Ca.

@article{Kozma2006ThePB,
  title={The progesterone-induced blocking factor modulates the balance of PKC and intracellular Ca.},
  author={No{\'e}mi Kozma and Melinda Hal{\'a}sz and Tam{\'a}s Palkovics and J{\'u}lia Szekeres-Barth{\'o}},
  journal={American journal of reproductive immunology},
  year={2006},
  volume={55 2},
  pages={122-9}
}
PROBLEM Progesterone-induced blocking factor (PIBF) induces Th2 biased cytokine production; therefore, this study investigates the effects of PIBF on the protein kinase C (PKC)/Ca(++) system - which plays a key role in Th1/Th2 differentiation. METHOD OF STUDY Proteins from PIBF-treated cells were reacted on Western blots with phospho-specific antibodies recognizing different PKC izoforms. Intracellular free calcium was measured by flow cytometry. RESULTS Both interleukin (IL)-4 and PIBF… CONTINUE READING
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