The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling

@article{Chekenya2008ThePC,
  title={The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling},
  author={Martha Chekenya and Camilla Krakstad and Agnete Svendsen and Inger Anne Netland and Vidar Staalesen and Berit B\olge Tysnes and Frode Selheim and J Wang and Per \Oystein Sakariassen and Tone Sandal and Per Eystein L\onning and T Flatmark and Per \Oyvind Enger and Rolf Bjerkvig and Mouldy Sioud and William B Stallcup},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={5182-5194}
}
Chemoresistance represents a major problem in the treatment of many malignancies. Overcoming this obstacle will require improved understanding of the mechanisms responsible for this phenomenon. The progenitor cell marker NG2/melanoma proteoglycan (MPG) is aberrantly expressed by various tumors, but its role in cell death signaling and its potential as a therapeutic target are largely unexplored. We have assessed cytotoxic drug-induced cell death in glioblastoma spheroids from 15 patients, as… CONTINUE READING

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