The profile of IgG1 and IgG2a antibody responses in mice exposed to Schistosoma mansoni.

@article{Mountford1994ThePO,
  title={The profile of IgG1 and IgG2a antibody responses in mice exposed to Schistosoma mansoni.},
  author={Adrian Paul Mountford and Amy Weaver Fisher and R Alan Wilson},
  journal={Parasite immunology},
  year={1994},
  volume={16 10},
  pages={521-7}
}
The segregation of IgG2a and IgG1 immunoglobulin isotypes as markers for Th1 and Th2 lymphocytes respectively, was investigated in mice exposed to normal or optimally-irradiated S. mansoni cercariae. Using a panel of ELISAs, soluble antigens from lung-stage schistosomula, adult worms, or eggs, were probed with serum samples collected at biweekly intervals. Infected mice developed increased IgG1 responsiveness to all three antigens, especially between weeks five and seven, whereas IgG2a… CONTINUE READING

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