The production of reactive oxygen species enhanced with the reduction of menadione by active thioredoxin reductase.

@article{Li2019ThePO,
  title={The production of reactive oxygen species enhanced with the reduction of menadione by active thioredoxin reductase.},
  author={Jing Li and Xin Zuo and Ping Cheng and Xiaoyuan Ren and Shibo Sun and Jianqiang Xu and Arne Holmgren and Jun Lu},
  journal={Metallomics : integrated biometal science},
  year={2019}
}
  • Jing Li, Xin Zuo, Jun Lu
  • Published 18 September 2019
  • Biology
  • Metallomics : integrated biometal science
Cytosolic thioredoxin reductase (TXNRD1) is an important selenoprotein that participates in the reduction of thioredoxin and many other redox-related substrates. The enhancement of ROS production to cause cancer cell death is an effective anticancer strategy. Herein, we found that menadione substantially increased ROS generation via interaction with TXNRD1. To elucidate the mechanism behind this, various TXNRD1 mutant proteins were used to investigate the relationship between ROS production and… 
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