The production of monoclonal antibodies from human lymphocytes.

  title={The production of monoclonal antibodies from human lymphocytes.},
  author={Danuta Kozbor and John C. C. Roder},
  journal={Immunology today},
  volume={4 3},
Two conceptually unique approaches are currently available for the production of human monoclonal antibodies - the 'hybridoma' technique, based on the fusion of antibody-producing B lymphocytes with plasmacytoma cells or lymphoblastoid cell lines; and the use of Epstein-Barr virus (EBV) to 'immortalize' antigen-specific, human B lymphocytes. Here Danuta Kozbor and, John Roder discuss the contribution each technique is making, alone or in combination, towards the desired aim of producing human… CONTINUE READING

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