The production of a new extracellular putative long-chain saturated polyester by smooth variants of Mycobacterium vaccae interferes with Th1-cytokine production

  title={The production of a new extracellular putative long-chain saturated polyester by smooth variants of Mycobacterium vaccae interferes with Th1-cytokine production},
  author={Elisabeth Rodr{\'i}guez-G{\"u}ell and Gemma Agust{\'i} and Merc{\`e} Corominas and Pere-Joan Cardona and Isidre Casals and Teodor Parella and Marco Sempere and Marina Luquin and Esther Juli{\'a}n},
  journal={Antonie van Leeuwenhoek},
Mycobacterium vaccae is of major pharmaceutical interest as an immunotherapeutic agent. Although M. vaccae 15483 ATCCT strain displays smooth and rough colonial morphologies on solid culture media, it is not known in which conditions M. vaccae switches from one colonial morphotype to the other or whether there are biological differences, especially immunological, between them. We have found that the change from a smooth to rough stable variant occurs spontaneously at 30 °C. The analysis of the… 

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