The production of KIR-Fc fusion proteins and their use in a multiplex HLA class I binding assay.

@article{Hilton2015ThePO,
  title={The production of KIR-Fc fusion proteins and their use in a multiplex HLA class I binding assay.},
  author={Hugo G Hilton and Achim K Moesta and Lisbeth A. Guethlein and Jeroen H Blokhuis and Peter R Parham and Paul J Norman},
  journal={Journal of immunological methods},
  year={2015},
  volume={425},
  pages={79-87}
}
Soluble recombinant proteins that comprise the extracellular part of a surface expressed receptor attached to the Fc region of an IgG antibody have facilitated the determination of ligand specificity for an array of immune system receptors. Among such receptors is the family of killer cell immunoglobulin-like receptors (KIR) that recognize HLA class I ligands. These receptors, expressed on natural killer (NK) cells and T cells, play important roles in both immune defense and placental… CONTINUE READING
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