The production and preclinical characterization of a chimeric anti-breast-cancer antibody, cBC2.

Abstract

A chimeric (mouse-human) BC2 antibody (cBC2) was produced which may be used in the diagnosis and treatment of breast cancer. The BC2 variable region genes were amplified by polymerase chain reaction (PCR), using oligonucleotide primers homologous to the framework sequences of mouse VH and V kappa genes. The PCR products were used to create cBC2 expression… (More)

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@article{Sutton1994ThePA, title={The production and preclinical characterization of a chimeric anti-breast-cancer antibody, cBC2.}, author={Virginia Sutton and J. Burgess and Gianni Pietersz and W. J. Li and Ian McKenzie and Joseph A. Trapani}, journal={Therapeutic immunology}, year={1994}, volume={1 2}, pages={83-93} }