The product of the imprinted gene IPL marks human villous cytotrophoblast and is lost in complete hydatidiform mole.

@article{Saxena2003ThePO,
  title={The product of the imprinted gene IPL marks human villous cytotrophoblast and is lost in complete hydatidiform mole.},
  author={Anjana Saxena and David M. Frank and Phonthakorn Panichkul and Ignatia B. van den Veyver and Benjamin Tycko and Harsh M Thaker},
  journal={Placenta},
  year={2003},
  volume={24 8-9},
  pages={
          835-42
        }
}
The IPL/TSSC3 gene is expressed nearly exclusively from the maternal allele, and its protein product acts to limit placental growth in mice. This protein specifically marks Type II trophoblast in the labyrinthine layer of the mouse placenta. To investigate mouse-human homologies, we carried out immunohistochemistry with antibodies against human IPL. There was strong expression of IPL in villous cytotrophoblast of the human placenta, contrasting with complete lack of expression in… CONTINUE READING

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