The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity.

@article{Akiyama1986ThePO,
  title={The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity.},
  author={Taishin Akiyama and C Sudo and Hiroshi Ogawara and Kumao Toyoshima and Tadashi Yamamoto},
  journal={Science},
  year={1986},
  volume={232 4758},
  pages={1644-6}
}
Antibodies were raised against a synthetic peptide corresponding to 14 amino acid residues at the COOH-terminus of a protein deduced from the human c-erbB-2 nucleotide sequence. These antibodies immunoprecipitated a 185-kilodalton glycoprotein from MKN-7 adenocarcinoma cells. Incubation of the immunoprecipitates with (gamma-32P)ATP resulted in the phosphorylation of this protein on tyrosine residues. These results indicate that the human c-erbB-2 gene product is the 185-kilodalton glycoprotein… CONTINUE READING
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