The processing of interleukin-1 beta studied with antibodies raised against synthetic peptides from the precursor N-terminal region.

@article{Schmidt1991ThePO,
  title={The processing of interleukin-1 beta studied with antibodies raised against synthetic peptides from the precursor N-terminal region.},
  author={John A. Schmidt and R Bomford},
  journal={Cytokine},
  year={1991},
  volume={3 3},
  pages={240-5}
}
The exact sequence of events during processing of human interleukin-1 beta (IL-1 beta) and the fate of the N-terminal region are unknown. We have used anti-peptide sera specific for the precursor and mature regions of IL-1 beta to study biosynthesis. These were raised against peptides corresponding to amino acids 1-15, 17-32, and 43-54 of the precursor and a peptide corresponding to the C-terminal 33 amino acids of mature human IL-1 beta. Antiserum to the mature region peptide… CONTINUE READING
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