The process of malignant progression in human breast cancer.

  title={The process of malignant progression in human breast cancer.},
  author={Robert Clarke and Robert B. Dickson and Nits Br{\"u}nner},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  volume={1 6},
Malignant progression in breast cancer represents the processes through which localized, hormone-dependent tumor cells become resistant to endocrine manipulations and metastasize to sites distant from the primary tumor. By selection in ovariectomized athymic nude mice, we have isolated a variant (MIII) of the hormone-dependent, poorly invasive, human breast cancer cell line MCF-7. MIII cells have lost their absolute requirement for estrogen to form proliferating tumors in nude mice. Furthermore… CONTINUE READING

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