The process of leukemogenesis.

  title={The process of leukemogenesis.},
  author={Richard D. Irons and Wayne S. Stillman},
  journal={Environmental Health Perspectives},
  pages={1239 - 1246}
Leukemias are monoclonal diseases that arise from cells in the hematopoietic stem and progenitor cell compartment. Consistent with emerging models of carcinogenesis, leukemogenesis is an evolutionary process that involves multiple independent genetic and epigenetic events. Over the last half-century a predominant paradigm has emerged to describe leukemia developing secondary to alkylating drug therapy or exposure to benzene in which progressive dysplastic changes, accompanied by a distinct… CONTINUE READING
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