The probiotic Lactobacillus plantarum counteracts TNF-{alpha}-induced downregulation of SMCT1 expression and function.

  title={The probiotic Lactobacillus plantarum counteracts TNF-\{alpha\}-induced downregulation of SMCT1 expression and function.},
  author={Alip Borthakur and Arivarasu Natarajan Anbazhagan and Anoop Kumar and Geetu Raheja and Varsha Singh and Krishnamurthy Ramaswamy and Pradeep K. Dudeja},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={299 4},
The major short-chain fatty acid (SCFA) butyrate is produced in the colonic lumen by bacterial fermentation of dietary fiber. Butyrate serves as primary fuel for the colonocytes and also ameliorates mucosal inflammation. Disturbed energy homeostasis seen in inflamed mucosa of inflammatory bowel disease patients has been attributed to impaired absorption of butyrate. Since sodium-coupled monocarboxylate transporter 1 (SMCT1, SLC5A8) has recently been shown to play a role in Na(+)-coupled… CONTINUE READING