The proapoptotic function of Drosophila Hid is conserved in mammalian cells.

Abstract

Three genes-reaper, grim, and hid-are crucial to the regulation of programmed cell death in Drosophila melanogaster. Mutations involving all three genes virtually abolish apoptosis during development, and homozygous hid mutants die as embryos with extensive defects in apoptosis. Although Hid is central to apoptosis in Drosophila, it has no mammalian… (More)

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@article{Haining1999ThePF, title={The proapoptotic function of Drosophila Hid is conserved in mammalian cells.}, author={W. Nicholas Haining and C Carboy-Newcomb and Chia-Lin Wei and Hermann Steller}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1999}, volume={96 9}, pages={4936-41} }