The proapoptotic Bcl-2 protein Bax plays an important role in the pathogenesis of reovirus encephalitis.

@article{Berens2011ThePB,
  title={The proapoptotic Bcl-2 protein Bax plays an important role in the pathogenesis of reovirus encephalitis.},
  author={Heather Marie Berens and Kenneth Lyle Tyler},
  journal={Journal of virology},
  year={2011},
  volume={85 8},
  pages={
          3858-71
        }
}
Encephalitis induced by reovirus serotype 3 (T3) strains results from the apoptotic death of infected neurons. Extrinsic apoptotic signaling is activated in reovirus-infected neurons in vitro and in vivo, but the role of intrinsic apoptosis signaling during encephalitis is largely unknown. Bax plays a key role in intrinsic apoptotic signaling in neurons by allowing the release of mitochondrial cytochrome c. We found Bax activation and cytochrome c release in neurons following infection of… CONTINUE READING

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