The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells.

@article{Oreilly2000ThePB,
  title={The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells.},
  author={Lorraine A O'reilly and Lara Cullen and Jane Visvader and Geoffrey J Lindeman and Cristin G. Print and Mary L. Bath and Dao Huang and Andreas Strasser},
  journal={The American journal of pathology},
  year={2000},
  volume={157 2},
  pages={449-61}
}
Proapoptotic Bcl-2 family members activate cell death by neutralizing their anti-apoptotic relatives, which in turn maintain cell viability by regulating the activation of the cell death effectors, the caspases. Bim belongs to a distinct subgroup of proapoptotic proteins that only resemble other Bcl-2 family members within the short BH3 domain. Gene targeting experiments in mice have shown that Bim is essential for the execution of some but not all apoptotic stimuli, for hematopoietic cell… CONTINUE READING

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