The pro-fibrogenic effect of nerve growth factor on conjunctival fibroblasts is mediated by transforming growth factor-beta.

@article{Micera2005ThePE,
  title={The pro-fibrogenic effect of nerve growth factor on conjunctival fibroblasts is mediated by transforming growth factor-beta.},
  author={Alessandra Micera and Ilaria Puxeddu and Alessandro Lambiase and Alessandro Antonelli and Stefano Bonini and Luigi Aloe and Jacob Pe'er and Francesca Levi-Schaffer},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2005},
  volume={35 5},
  pages={650-6}
}
BACKGROUND Nerve growth factor (NGF) and nerve growth factor receptor (NGFR) expressions have been found to be increased in sub-conjunctival scarring. OBJECTIVE The aim of this study was to investigate the in vitro effects of NGF on some pro-fibrogenic properties of human conjunctival fibroblasts. METHODS Expression of NGF, trkA(NGFR) and p75NTR on human fibroblasts grown from conjunctival biopsies and incubated for 2 or 6 days with NGF were evaluated by immunofluorescence, RT-PCR, flow… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Studies on Neurotrophins in Inflammatory Pulmonary Diseases

Charlotta Dagnell, Till Markus ABSTRACT
2010
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…