The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo.

@article{Stallock2003ThePG,
  title={The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo.},
  author={James Stallock and Kathy Molyneaux and Kyle Schaible and C. Michael Knudson and Christopher Wylie},
  journal={Development},
  year={2003},
  volume={130 26},
  pages={6589-97}
}
In the mouse embryo, significant numbers of primordial germ cells (PGCs) fail to migrate correctly to the genital ridges early in organogenesis. These usually die in ectopic locations. In humans, 50% of pediatric germ line tumors arise outside the gonads, and these are thought to arise from PGCs that fail to die in ectopic locations. We show that the pro-apoptotic gene Bax, previously shown to be required for germ cell death during later stages of their differentiation in the gonads, is also… CONTINUE READING

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