The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine

Abstract

BACKGROUND Alterations in gene splicing occur in human sporadic colorectal cancer (CRC) and may contribute to tumour progression. The K-ras proto-oncogene encodes two splice variants, K-ras 4A and 4B, and K-ras activating mutations which jointly affect both isoforms are prevalent in CRC. Past studies have established that splicing of both the K-ras oncogene… (More)
DOI: 10.1186/1471-230X-8-24

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@article{Patek2008ThePK, title={The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine}, author={Charles E. Patek and Mark J Arends and Lorraine Rose and Feijun Luo and Marion Walker and Paul S. Devenney and Rachel L. Berry and Nicola J. Lawrence and Rachel A. Ridgway and Owen James Sansom and Martin Leslie Hooper}, journal={BMC Gastroenterology}, year={2008}, volume={8}, pages={24 - 24} }