The pro- and anti-inflammatory properties of the cytokine interleukin-6.

  title={The pro- and anti-inflammatory properties of the cytokine interleukin-6.},
  author={J{\"u}rgen Scheller and Athena Chalaris and Dirk Schmidt-Arras and Stefan Rose-John},
  journal={Biochimica et biophysica acta},
  volume={1813 5},
Interleukin-6 is a cytokine not only involved in inflammation and infection responses but also in the regulation of metabolic, regenerative, and neural processes. In classic signaling, interleukin-6 stimulates target cells via a membrane bound interleukin-6 receptor, which upon ligand binding associates with the signaling receptor protein gp130. Gp130 dimerizes, leading to the activation of Janus kinases and subsequent phosphorylation of tyrosine residues within the cytoplasmic portion of gp130… CONTINUE READING
Highly Influential
This paper has highly influenced 40 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS