The pro‐apoptotic effect of quercetin in cancer cell lines requires ERβ‐dependent signals

@article{Bulzomi2012ThePE,
  title={The pro‐apoptotic effect of quercetin in cancer cell lines requires ER$\beta$‐dependent signals},
  author={Pamela Bulzomi and Paola Galluzzo and Alessandro Bolli and Stefano Leone and Filippo Acconcia and Maria Marino},
  journal={Journal of Cellular Physiology},
  year={2012},
  volume={227}
}
Quercetin has potentially beneficial effects on disease prevention, including cancer. An intriguing issue regarding the mechanisms of action of quercetin is the ability of this drug to modulate estrogen receptor (ER) activities. In a previous study, we demonstrated that quercetin elicited apoptosis through an ERα‐dependent mechanism. However, the contribution of ERβ in quercetin‐induced apoptosis remains elusive. Here, we report that quercetin, at nutritionally relevant concentrations, mimicked… Expand
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