The prion protein unstructured N-terminal region is a broad-spectrum molecular sensor with diverse and contrasting potential functions.

Abstract

The physiological function of the prion protein (PrP(C) ) and its conversion into its infectious form (PrP(Sc) ) are central issues to understanding the pathogenesis of prion diseases. The N-terminal moiety of PrP(C) (NH(2) -PrP(C) ) is an unstructured region with the characteristic of interacting with a broad range of partners. These interactions endow PrP… (More)
DOI: 10.1111/j.1471-4159.2011.07613.x

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Cite this paper

@article{Bland2012ThePP, title={The prion protein unstructured N-terminal region is a broad-spectrum molecular sensor with diverse and contrasting potential functions.}, author={Maxime B{\'e}land and Xavier Roucou}, journal={Journal of neurochemistry}, year={2012}, volume={120 6}, pages={853-68} }