The prion protein has DNA strand transfer properties similar to retroviral nucleocapsid protein.

@article{Gabus2001ThePP,
  title={The prion protein has DNA strand transfer properties similar to retroviral nucleocapsid protein.},
  author={C. Gabus and Sylvie Auxilien and Christine P{\'e}choux and Dominique Dormont and Wieslaw Swietnicki and Manuel Morillas and Witold K Surewicz and Pradip K. Nandi and J. L. Darlix},
  journal={Journal of molecular biology},
  year={2001},
  volume={307 4},
  pages={1011-21}
}
The transmissible spongiform encephalopathies are fatal neurodegenerative diseases that are associated with the accumulation of a protease-resistant form of the cellular prion protein (PrP). Although PrP is highly conserved and widely expressed in vertebrates, its function remains a matter of speculation. Indeed PrP null mice develop normally and are healthy. Recent results show that PrP binds to nucleic acids in vitro and is found associated with retroviral particles. Furthermore, in mice the… CONTINUE READING
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