The prion model for [URE3] of yeast: spontaneous generation and requirements for propagation.

@article{Masison1997ThePM,
  title={The prion model for [URE3] of yeast: spontaneous generation and requirements for propagation.},
  author={Daniel C Masison and M. L. Maddelein and Reed B Wickner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 23},
  pages={12503-8}
}
The genetic properties of the non-Mendelian element, [URE3], suggest that it is a prion (infectious protein) form of Ure2p, a mediator of nitrogen regulation in Saccharomyces cerevisiae. Into a ure2Delta strain (necessarily lacking [URE3]), we introduced a plasmid overproducing Ure2p. This induced the frequent "spontaneous generation" of [URE3], with properties identical to the original [URE3]. Altering the translational frame only in the prion-inducing domain of URE2 shows that it is Ure2… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Masison et al

  • M. Fischer, T. Rulicke, +8 authors 1255–1264. 12508 Genetics
  • Proc. Natl. Acad. Sci. USA 94
  • 1997
1 Excerpt

Prion Diseases of Mammals and Yeast: Molecular Mechanisms and Genetic Features (Landes, Austin, TX)

  • R. B. Wickner
  • 1997

Similar Papers

Loading similar papers…