The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells

@article{Tang2006ThePU,
  title={The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells},
  author={Li Tang and Guolin Li and Liguo Song and Yuesheng Zhang},
  journal={Anti-Cancer Drugs},
  year={2006},
  volume={17},
  pages={297-305}
}
Isothiocyanates (ITCs) are a class of well-known cancerpreventive phytochemicals, but are primarily disposed of and concentrated in the urine as N-acetylcysteine conjugates (NAC-ITCs) in vivo. Because human urinary bladder cancers occur almost exclusively in the bladder epithelium, which is directly exposed to the urine stored in the bladder, we undertook to examine the anti-cancer activity of NAC-ITCs in cultured human bladder cancer cells. In this paper, we report that the NAC conjugates of… Expand
Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion.
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This work supports development of fully characterized, novel food products containing broccoli components for phase I/II human studies targeting bladder cancer prevention and determines the role of isothiocyanates in primary or secondary bladder cancer Prevention. Expand
Inhibition of urinary bladder carcinogenesis by broccoli sprouts.
TLDR
It is reported that dietary administration to rats of a freeze-dried aqueous extract of broccoli sprouts significantly and dose-dependently inhibited bladder cancer development induced by N-butyl-N-(4-hydroxybutyl) nitrosamine and the isothiocyanates in the extract are selectively delivered to the bladder epithelium through urinary excretion. Expand
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Allyl isothiocyanate as a cancer chemopreventive phytochemical.
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  • Biology, Medicine
  • Molecular nutrition & food research
  • 2010
TLDR
It is suggested that AITC may be most effective in the bladder as a cancer chemopreventive compound and further studies are warranted in order to elucidate its mechanism of action and to assess its protective activity in humans. Expand
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  • Chemistry, Medicine
  • Carcinogenesis
  • 2012
TLDR
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TLDR
This review focuses on the anti-cancer effects of isothiocyanates (ITCs) derived from cruciferous vegetables, which are widely cultivated and consumed in many regions worldwide and have the carcinogenic potential of ITCs. Expand
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TLDR
Three metabolites derived from SFN exhibited similar cytotoxic and cytoprotective effects to SFN, which proves the necessity to study the mechanisms of action of not only SFN but also of its metabolites. Expand
Proteins as binding targets of isothiocyanates in cancer prevention.
TLDR
All potential protein targets of ITCs so far studied are covered and what is known about their binding sites and the potential biological consequences are summarized and discussions to shed light onto the relationship between protein binding and reactive oxygen species generation by I TCs are offered. Expand
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