The principal sigma factor sigA mediates enhanced growth of Mycobacterium tuberculosis in vivo.

@article{Wu2004ThePS,
  title={The principal sigma factor sigA mediates enhanced growth of Mycobacterium tuberculosis in vivo.},
  author={Shiping Wu and Susan T. Howard and David L. Lakey and Andr{\'e} Kipnis and Buka Samten and Hassan Safi and Veronica Gruppo and Benjamin Wizel and Homayoun Shams and Randall J Basaraba and Crystal Shanley and Peter F. Barnes},
  journal={Molecular microbiology},
  year={2004},
  volume={51 6},
  pages={
          1551-62
        }
}
The ability of Mycobacterium tuberculosis to grow in macrophages is central to its pathogenicity. We found previously that the widespread 210 strain of M. tuberculosis grew more rapidly than other strains in human macrophages. Because principal sigma factors influence virulence in some bacteria, we analysed mRNA expression of the principal sigma factor, sigA, in M. tuberculosis isolates during growth in human macrophages. Isolates of the 210 strain had higher sigA mRNA levels and higher… CONTINUE READING
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