The principal features and mechanisms of dopamine modulation in the prefrontal cortex

@article{Seamans2004ThePF,
  title={The principal features and mechanisms of dopamine modulation in the prefrontal cortex},
  author={Jeremy K. Seamans and Charles R. Yang},
  journal={Progress in Neurobiology},
  year={2004},
  volume={74},
  pages={1-58}
}
Mesocortical [corrected] dopamine (DA) inputs to the prefrontal cortex (PFC) play a critical role in normal cognitive process and neuropsychiatic pathologies. This DA input regulates aspects of working memory function, planning and attention, and its dysfunctions may underlie positive and negative symptoms and cognitive deficits associated with schizophrenia. Despite intense research, there is still a lack of clear understanding of the basic principles of actions of DA in the PFC. In recent… CONTINUE READING
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