The primate subthalamic nucleus. III. Changes in motor behavior and neuronal activity in the internal pallidum induced by subthalamic inactivation in the MPTP model of parkinsonism.

@article{Wichmann1994ThePS,
  title={The primate subthalamic nucleus. III. Changes in motor behavior and neuronal activity in the internal pallidum induced by subthalamic inactivation in the MPTP model of parkinsonism.},
  author={Thomas Wichmann and Hagai Bergman and Mahlon R. Delong},
  journal={Journal of neurophysiology},
  year={1994},
  volume={72 2},
  pages={521-30}
}
1. The effects of reversible and irreversible pharmacological manipulations of the neuronal activity in the subthalamic nucleus (STN) on parkinsonian motor signs and neuronal activity in the internal segment of the globus pallidus (GPi) were studied in African green monkeys rendered parkinsonian by treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. 2. Muscimol injections (< or = 1 microliter, 1 microgram/microliter) into STN reduced neuronal activity recorded at the injection site… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
162 Citations
51 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 162 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Altered tonic activity of neurons in the globus pallidus and subthalamic nucleus in the primate MPTP model of parkinsonism

  • W. C. MILLER, M. R. DELONG
  • The Basal Ganglia II,
  • 1987
Highly Influential
4 Excerpts

Antiparkinsonian effect of subthalmotomy in MPTP-exposed monkeys (Abstract)

  • J. GURIDI, M. R. LUGUIN, M. T. HERRERO, J. GUILLEN, J. A. OBESO
  • Movement Disorders
  • 1993
2 Excerpts

GABA delivery to the subthalamic nucleus alleviates MPTP induced hemiparkinsonism in non-human primates

  • A. P. SIGNORE, M. GODDARD, P. AEBISCHER
  • Sot. Neurosci. Abstr
  • 1993
1 Excerpt

Lesions in the sensorimotor regions of the internal segment of the globus pallidus in parkinsonian patients are effective in alleviating the cardinal signs of Parkinson’s disease

  • M. BARON, J. VITEK, R. TURNER, Y. KANEOKE, R. BAKAY, M. R. DELONG
  • Sot. Neurosci. Abstr
  • 1993
2 Excerpts

Similar Papers

Loading similar papers…