The primate autoimmune encephalomyelitis model; a bridge between mouse and man

  title={The primate autoimmune encephalomyelitis model; a bridge between mouse and man},
  author={Bert Adriaan ‘t Hart and Yvette van Kooyk and J. J. G. Geurts and Bruno Gran},
  booktitle={Annals of clinical and translational neurology},
INTRODUCTION Multiple sclerosis (MS) is an enigmatic autoimmune-driven inflammatory/demyelinating disease of the human central nervous system (CNS), affecting brain, spinal cord, and optic nerves. The cause of the disease is not known and the number of effective treatments is limited. Despite some clear successes, translation of immunological discoveries in the mouse experimental autoimmune encephalomyelitis (EAE) model into effective therapies for MS patients has been difficult. This… CONTINUE READING
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Improvement of preclinical animal models for autoimmune - mediated disorders via reverse translation of failed therapies

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