The primary transcriptome of the major human pathogen Helicobacter pylori

  title={The primary transcriptome of the major human pathogen Helicobacter pylori},
  author={Cynthia M. Sharma and S. Hoffmann and Fabien Darfeuille and J. Reignier and Sven Findei{\ss} and A. Sittka and Sandrine Chabas and K. Reiche and J. Hackerm{\"u}ller and R. Reinhardt and P. Stadler and J. Vogel},
  • Cynthia M. Sharma, S. Hoffmann, +9 authors J. Vogel
  • Published 2010
  • Biology, Medicine, Computer Science
  • Nature
  • Genome sequencing of Helicobacter pylori has revealed the potential proteins and genetic diversity of this prevalent human pathogen, yet little is known about its transcriptional organization and noncoding RNA output. Massively parallel cDNA sequencing (RNA-seq) has been revolutionizing global transcriptomic analysis. Here, using a novel differential approach (dRNA-seq) selective for the 5′ end of primary transcripts, we present a genome-wide map of H. pylori transcriptional start sites and… CONTINUE READING
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