The primary transcriptome of the major human pathogen Helicobacter pylori

  title={The primary transcriptome of the major human pathogen Helicobacter pylori},
  author={Cynthia M. Sharma and Steve Hoffmann and Fabien Darfeuille and J{\'e}r{\'e}my Reignier and Sven Findei\ss and Alexandra Sittka and Sandrine Chabas and Kristin Reiche and J{\"o}rg Hackerm{\"u}ller and Richard Reinhardt and Peter F. Stadler and J{\"o}rg Vogel},
Genome sequencing of Helicobacter pylori has revealed the potential proteins and genetic diversity of this prevalent human pathogen, yet little is known about its transcriptional organization and noncoding RNA output. Massively parallel cDNA sequencing (RNA-seq) has been revolutionizing global transcriptomic analysis. Here, using a novel differential approach (dRNA-seq) selective for the 5′ end of primary transcripts, we present a genome-wide map of H. pylori transcriptional start sites and… CONTINUE READING
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