The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxim.

@article{Michalek1980ThePR,
  title={The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxim.},
  author={Suzanne M. Michalek and Robert N. Moore and Jerry R. Mcghee and David L. Rosenstreich and Stephan E. Mergenhagen},
  journal={The Journal of infectious diseases},
  year={1980},
  volume={141 1},
  pages={55-63}
}
Mice that are unresponsive to lipopolysaccharide (LPS) (strain C3H/HeJ) can be rendered LPS-sensitive by the adoptive transfer of bone marrow cells from LPS-sensitive mice (strain C3H/HeN). This model of adoptive transfer was used to evaluate the contribution of lymphoreticular cells to five effects of endotoxin on the host: immunogenicity, adjuvanticity, lethality, induction of interferon, and induction of colony-stimulated factor. C3H//HeJ mice became sensitive to each of these effects after… CONTINUE READING

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