The primary effect of the Ity locus is on the rate of growth of Salmonella typhimurium that are relatively protected from killing.

@article{Benjamin1990ThePE,
  title={The primary effect of the Ity locus is on the rate of growth of Salmonella typhimurium that are relatively protected from killing.},
  author={William H. Benjamin and Pam Hall and StevenA. Roberts and David E. Briles},
  journal={Journal of immunology},
  year={1990},
  volume={144 8},
  pages={3143-51}
}
The Ity locus affects the net increase in numbers of Salmonella typhimurium in the liver and spleen of infected mice. There has been controversy, however, about whether the effects of this locus are due to differential killing of S. typhimurium or differential growth rates of S. typhimurium in mice. Our studies using S. typhimurium aroA mutants, which do not grow in vivo, demonstrate that growth of the infecting salmonella is necessary for the observation of the Ity phenotype. To examine the… CONTINUE READING

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