The primary cilium: a signalling centre during vertebrate development

  title={The primary cilium: a signalling centre during vertebrate development},
  author={Sarah C Goetz and Kathryn V Anderson},
  journal={Nature Reviews Genetics},
The primary cilium has recently stepped into the spotlight, as a flood of data show that this organelle has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for hedgehog signal transduction. The formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The cilium therefore… CONTINUE READING
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Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts.

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The Bardet–Biedl syndromeassociated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signalling

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